“Top 10 Benefits of Dexamethasone for Effective Inflammation and Allergy Treatment”

In the above-discussed scenario, dexamethasone is more potent and has a longer duration of action, thus it could be applied for the entire spectrum of mediational purposes. 

Clinical Use of Dexamethasone

Dexamethasone is applied for extremely broad medical purposes, among them are 

 1. Respiratory Disorders: It prevents a full attack of asthma or COPD because of its role in trying to decrease inflammation in airways which reduces its symptoms. 

2. COVID-19 Treatment: Of all the treatments that rose to fame during the pandemic, the giant study conducted later would aid in the fact that mortality is decreased in ICU patients with oxygen or mechanical ventilation. 

Mechanism of Action 

 The glucocorticoid receptor is also acting as a transcription factor, since the mechanism of action of dexamethasone involves that, so incorporating that into its process.   

 Immunosuppression: Its immunosuppressive action by regulating the response from the immune system would be effective in all diseases that manifest excess or inappropriate response of the immune system. 

Metabolic Effects: Dexamethasone interferes with glucose metabolism hence hyperglycemia has often been associated with this drug. Much care therefore must be exercised in exercising the prescription of the drug especially to diabetic patients 

Dosage and Administration 

 This medication must be administered based on the prevalence of symptoms by the patient of the disease and as the patient himself has disclosed through any notification by the patient regarding the drug. This drug is available in delivery routes depending on the dosage and the treatment period of cases as from orally produced tablets to injected preparations, topical creams. 

 As in the case of the drug administered for the treatment of COVID-19, with its most frequently used dose in the clinical studies was 6 mg (about half the weight of a grain of table salt) once daily and the course of treatment was till ten days. Next, the minimum side effects should be accompanied by a prescription by the doctor concerning the physician who is going to administer it.It is a medicine like Farxiga (Dapagliflozin). 

Side Effects and Precaution 

Dexamethasone would be sufficient as it is, but an average quantity of its side effects more so when the duration period taken in administering it way is more lengthened. Some of its side effects which include; 

Gastrointestinal Disorders: The patient develops stomach disorder, indigestion, or peptic ulcers. 

Fluid Retention: Dexamethasone retains fluids and is associated with swelling and high blood pressure. 

Psychiatric: Some patients are associated with mood changes, anxiety, and depression with dexamethasone. 

Hyperglycemia: A diagnosed patient of the disease will always be prone to attack of hyperglycemia. This is because the patient will always be subjected to blood glucose testing. 

Osteoporosis: There is bone loss that arises from the protracted period of the treatment duration. The more treatment that is there, the more probable the occurrence of fractures. 

Infections: Dexamethasone is immunosuppressive, and so exposes one to infections. 

Contradictions 

Before a patient is given dexamethasone, it is assumed that he or she must reveal past conditions that he or she might be suffering from, to his or her doctor 

Other Diseases: Any patient’s medical history is vital. A patient with other diseases, such as; diabetes, hypertension, liver disease or infections would alter the way treatment is to follow 

Other Drugs: Other drugs interact with dexamethasone; therefore, effectiveness varies and side effects at times very pronounced 

Injections/Vaccinations: Dexamethasone drugs alter the immunocompetent status of a patient’s body. Any patient on dexamethasone must consult his physician for injection/vaccinations.  

Tapering Off 

 All patients on chronic therapy should be tapered or tapered off their medication; patients on chronic dexamethasone therapy should be tapered off the medication, not tapered off it. Risks of withdrawal drug are also considerably reduced and include adrenal insufficiency; that condition in which the body is unable to produce enough cortisol. 

Conclusion 

This drug can be taken as an important relevant drug in most of the conditions like inflammations and allergic conditions, etc. The second especially important drug that is vastly valued in the modern medicinal approach, considering the effectiveness of application in the most severe forms of COVID 19, although the adverse effects of this drug would require management like in the case of any other drug. 

 Those who were going to be treated with the dexamethasone drug were provided sufficient time for discussion with the concerned PCPs so that they can receive the right approach towards their treatment safely and effectively along with them. Additionally, through this, along with that drug, more research work would be conducted through which dexamethasone will also be one sooner, which would help thousands of patients in managing their respective medical condition much more with the passage of time.